The Genetics Center, Inc.   Address, phone, and fax
Rapid Prenatal Chromosome Diagnosis:

Straightforward answers to
important questions

Rapid prenatal chromosome diagnosis is very useful in selected circumstances.  Unlike conventional chromosome analysis on an amniocentesis or chorionic villus sample, which can take up to 14 days because the procedure entails culturing cells, this technique enables identification of Down syndrome and certain other chromosome abnormalities in 24 to 72 hours.

What is rapid prenatal diagnosis?

Fluorescent DNA probes are used to analyze the chromosome makeup of cells obtained from amniotic fluid or a chorionic villus sample (CVS). While not all chromosome abnormalities can be identified by this technique, the majority of common abnormalities can be identified.  These include Down syndrome (trisomy 21), trisomy 18, trisomy 13, Klinefelter syndrome (47,XXY), triple-X syndrome (47,XXX), Turner syndrome (45,X) and 47,XYY. The technique is  known as interphase FISH, which stands for fluorescent in situ hybridization, or simply as FISH. Our laboratory uses the AneuVysion test, which has been cleared by the FDA for this purpose.
When should this be considered?
Sometimes important pregnancy management decisions need to be made quickly, while waiting for a complete cytogenetic result.  The following are some of the situations in which a rapid assay may be helpful.
What are limitations of rapid prenatal diagnosis?

Genetic consultation for patients undergoing prenatal diagnosis, including rapid prenatal diagnosis, is often very helpful.  This can help patients understand limitations of prenatal diagnosis and FISH analysis and enables physicians to order the optimal combination of prenatal diagnostic analyses.


Services | Insurance | Directions | Glossary | Genetics links | Topics of Interest | Our Staff | Pictures | Privacy Policy | Contact us | Home

 © 2003 The Genetics Center, Inc., All Rights Reserved                                                                                        This page last updated February 8, 2013